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Hard Drive Usage

I have a several hundred line specification running on an 80 core HPC and after a day it is using 423GB of space. While I believe it is close to finished it is probably going to run out of space before it does. Is there a way to run TLC that uses less HDD space? I mean, there is 865GB of RAM in this machine. So I actually have more RAM available then HDD. It's currently only using 91 GB of RAM.